According to Business Insider, a NASA article from 1995 shows the toxic effects of drugs on the brain after administering caffeine, marijuana, and benzedrine to spiders before they spun their webs.
The researchers noticed that the more toxic the drug administered, the more deformed and wild the web looked compared to the normal control web. The patterns created by these spiders after being exposed to caffeine and other chemicals has made researchers question the effects of caffeine on the brain.
Scientists have not concluded that caffeine creates the same detrimental effects in humans and have found a correlation between drinking two cups of coffee a day and a decrease in the risk of dying from cancer, cardiovascular disease, and diabetes.
Caffeine blocks the chemical adenosine which tells your brain you’re tired and then the caffeine releases stimulants like dopamine, adrenaline, and glutamate in large amounts into your brain. The 1995 study is an interesting study into the effects of different drugs on spiders and the good and bad effects that they have on us.